A flavivirus genome-derived noncoding RNA regulates T cell function and restricts virus replication

Séminaires
Date: vendredi 21 février 2020 11:00

Lieu: salle Marcel Dorée, CNRS campus  |  Ville: Montpellier, France

Dear all,
 
On Friday the 21st of Feb at 11 am (salle Marcel Dorée, CNRS campus), Prof. Jack Stapleton, from Iowa university, will be presenting some of his recent work, entitled:
«  A flavivirus genome-derived noncoding RNA regulates T cell function and restricts virus replication ».
 
Jack Stapleton's minibio: Jack is a Professor of Internal Medicine, Infectious Diseases and Microbiology at the University of Iowa.  Over the last 3 decades, his laboratory has focused on positive strand RNA viruses (HIV, HCV, GBV-C/HPgv) and how members of the Flaviviridae interact with HIV and immune function.  Most recently, the lab studies how HCV and yellow fever virus genomic RNA is processed into short, noncoding RNAs that regulate T cell function and enhance viral replication.  He also has conducted numerous translational studies on how human pegivirus (GBV-C) prolongs survival in HIV infected people, and characterized mechanisms involved in this beneficial co-infection.
 
Jack Stapleton ’s recent publications:
- Welch JL, Kaddour H, Schlievert PM, Stapleton JT, Okeoma CM.  Semen exosomes promote transcriptional silencing of HIV-1 by disrupting NF-kB/Sp1/Tat circuitry.  J Virol 92:e00731-18, 2018.
- Fama A, Xiang J, Link BK, Allmer C, Klinzman D, Feldman AL, Nowakowski GS, Liebow M, Larson MC, Maurer MJ, Ansell SM, Novak AJ, Asmann YW, Slager SL, Call TG, Habermann TM, Cerhan JR, Stapleton JT.  Human Pegivirus (HPgV) infection and lymphoma risk and prognosis: A North American study.  Br J Haematol, 182:644-653, 2018.
- McLinden JH, Bhattarai N, Stapleton JT, Chang Q, Kaufman TM, Cassel SL, Sutterwala FS, Haim H, Houtman J, Xiang J.  Yellow fever virus, but not Zika or Dengue virus inhibits T cell receptor-mediated T cell function by an RNA-based mechanism.  J Infect Dis, 216:1164-1175, 2017.
- Bhattarai N, McLinden JH, Xiang J, Mathahs MM, Schmidt WN, Kaufman TM, Stapleton JT.  Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo.  PLoS Pathogens, 13:e1006232, 2017.
 
Jack will be spending the next few months on a sabbatical in my lab. If you wish to meet with him, just let us know!

 

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  • vendredi 21 février 2020 11:00
 

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