Non-canonical Roles of Argonaute proteins in HIV-1 viral RNA expression

Séminaires
Date: vendredi 13 décembre 2019 11:00

Lieu: Salle Marcel Dorée  |  Ville: Montpellier, France

Sarah Gallois-Montbrun from Institut Cochin

 

Talk summary: During its replication, HIV-1 produces more than 50 different transcripts coding for all the proteins necessary for viral particle assembly. Balanced production of viral isoforms is highly regulated both temporally and spatially. Current research in Sarah’s group aims at characterizing the role of viral and cellular factors involved in HIV-1 RNA production. In particular, they investigated the role of the miRNA pathway and demonstrated that key proteins of these pathway, Argonaute 1 and Argonaute 2, participate at different levels of viral RNA production independently of the presence of miRNA. In parallel, they recently developed a long-read sequencing assay to quantify production of HIV-1 isoforms and to decipher the cascade of splicing events taking place at early time points after infection. 


Dr Gallois-Montbrun's minibiography: After completing her PhD studies at Pasteur Institute Paris in 2004 on cellular metabolism of anti-HIV-1 drugs, she undertook post-doctoral training with Prof Michael Malim at King’s College London. There she focused on characterizing cellular protein and RNA partners of APOBEC3G and APOBEC3F, two HIV-1 restriction factors. She was recruited as Inserm research scientist at Cochin Institute in 2009.  Since then, her group has aimed at dissecting mechanisms regulating HIV-1 RNA fate and how these impact on viral replication.

 

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Adresse
1919 Route de Mende
34090 Montpellier, France

 

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  • vendredi 13 décembre 2019 11:00
 

Propulsé par iCagenda

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